Article: Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Usowicz MM; Garden CL Brain Res., 2012
wild-type | Ts65Dn mice | |
---|---|---|
input capacitance (pF) | 3 (48) | 3.8 (40) |
resting membrane potential (mV) | −80.0 ± 0.3 (38) | −79.7 ± 0.5 (21) |
AP voltage threshold (mV) | −47.8 (37) | −47.8 (20) |
first spike latency (ms) | 182.9 ± 18.7 (33) | 181.9 ± 19.9 (20) |
AP amplitude, peak to trough (mV) | 99.4 ± 1.4 (33) | 103.8 ± 1.1 (20) |
AP amplitude, threshold to peak (mV) | 75.2 ± 1.4 (33) | 79.6 ± 1.1 (20) |
AP half-width (μs) | 714.9 ± 25.9 (33) | 643.5 ± 15.4 (20) |
AP overshoot (mV) | 27.5 | 32 |
AHP voltage (mV) | -72 | -72 |
: |